Effects of Tocotrienol Supplementation on Hair Growth in Human Volunteers
补充三烯生育醇对头发生长的影响
研究结果与讨论
三十八位有异常掉发情况或秃头的志愿受试者参加了研究，口服三烯生育醇组有21名志愿者（19男2女），安慰剂组（对照组）有17个志愿者（全部为男性）。该研究的人口年龄介于 18至59岁。受试者年龄范围广泛，因为掉发是不受年龄之限制。年轻的成年人与老年人都会有受到掉发问题的影响。此外，掉发可能是由于营养缺乏和氧化压力所导致，从而影响广泛的年龄组。受试者掉发问题大约有2~5年的时间。
研究开始前，针对受试组成员的头发数以及头发重量加以评估。安慰剂组受试者的毛发的平均数目基线为289.0 ± 98.3，而补充三烯生育醇组为284.8 ± 111.3。至于20股头发平均重量，安慰剂组受试者的毛发的平均数目基线为0.1002克和 ±0.0639，而补充三烯生育醇组为0.0920 ± 0.0565克。比较两组的两个参数并没有显著差异（P> 0.05）。
三十五位受试者完成了整个研究，并评价补充三烯生育醇的效果。三名受试者中止研究，一位(女)是三烯生育醇组，和两位安慰剂组。每个月记录与访视过程中，补充三烯生育醇的顺从性是令人满意的。两组皆无严重药物反应或有关的记录。从而表明，持续8个月服用100毫克的生育三烯酚是可以忍受的。研究方案也被认为是令人满意的，没有偏差协定的记录。
表1显示了受试者在基线，第4和第8个月的头发数量变化，以及发量增加的百分比变化。显而易见的是，三烯生育醇补充组，从基线到第8个月的时间，头发数量有逐渐增加，最后平均增幅超过 34％。相比之下，安慰剂组受试者没有表现出任何明显的发量增加，约减少0.1％。杜克的事后检验表明(Tukey’s post-hoc test)，补充三烯生育醇的受试者头发增加并无安慰剂效应。成对比较还表明，8个月的时间，补充三烯生育醇组和安慰剂组噢试者的头发数量有显著差异。
研究结束时，对于头发数量增加的效果评估，有一个志愿受试者例外。整体而言，8名志愿者（40.0％）显示头发增加了50％以上，1名志愿（5.0％）有25％至50％的增幅，9名受试者（45.0％）有增加10％至25％，而1名受试者（5.0％ ）为头发增加不到10％。只有1名受试者（5.0％）发量有些微减少。另一方面，在8个月后，在安慰剂组有8个志愿者显示有增加头发的数量，1名（6.7％），显示超过 20％的增长，其余 7名（46.7％），显示微不足道(negligible)的增加。7名受试者（46.7％）头发减少。
然而，两组的头发重量并没有显著增加。三烯生育醇补充组，平均百分比增重了5.9％的，而安慰剂组有轻微下降2.0％（见表 2）。研究结果之后，另行补充相关的研究显示，抗氧化剂可能被用来控制雄性秃掉发。
结论
总之，本试验表明，补充三烯生育醇胶囊的受试者与安慰剂组相比，头发数量有增加。一种可能的解释，效果可能是由于强大的抗氧化活性的生育三烯醇，以帮助降低头皮的脂质过氧化和氧化压力。
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