到底要服用多少剂量的Finasteride才是最适当也最有效的? 这一直是雄性秃朋友们最关切的议题。



5mg、 2.5mg、1.25mg、1mg，在大家的经验分享中，都有朋友再吃。我们也可以发现摄取Finasteride剂量越高，即便心理上对预期效果是有正 增强的‘药效’，实际上效果也不见得呈倍数成长，但副作用的机率也会跟着提高一些。前镇子在车上收听广播，听到台大皮肤科蔡呈芳医师提到，日本有实验指出 0.2mg的Finasteride就具有治疗雄性秃的效果，当时还令我觉得不可思议。最近找到了这篇研究，配合上国外一些医师的看法，来多了解  Finasteride的效果啰。 
Eur J Dermatol. 2004 Jul-Aug;14(4):247-54.
Finasteride in the treatment of Japanese men with male pattern hair loss.
口服Finasteride治疗日本男性雄性秃患者的研究
Kawashima M,  Hayashi N, Igarashi A, Kitahara H, Maeguchi M, Mizuno A, Murata Y,  Nogita T, Toda K, Tsuboi R, Ueki R, Yamada M, Yamazaki M, Matsuda T,  Natsumeda Y, Takahashi K, Harada S.
Tokyo Women's Medical University,  School of Medicine, Department of Dermatology 8-1, Kawada-cho, Shinjuku  Tokyo, 162-8666 Japan. m-kawash@derm.twmu.ac.jp
东京女子医科大学医学院皮肤科，川田町，新宿东京162-8666日本。 
摘要
Finasteride  is a type 2 5 alpha-reductase inhibitor that inhibits conversion of  testosterone to dihydrotestosterone, a key mediator of male pattern hair  loss (androgenetic alopecia). The objective of this study was to  identify the optimal dosage of finasteride and to evaluate its efficacy  and safety in the treatment of Japanese men with male pattern hair loss.  In this double- blind randomized study, 414 Japanese men with male  pattern hair loss received finasteride 1 mg (n = 139), finasteride 0.2  mg (n = 137), or placebo (n = 38) once daily for 48 weeks. Efficacy was  evaluated by global photographic assessment, patient self-assessment,  and investigator assessment. All efficacy endpoints showed significant  improvement with finasteride therapy by 12 weeks (p < 0.05 versus  placebo). At 48 weeks, 58%, 54%, and 6% of men in the finasteride 1 mg,  finasteride 0.2 mg, and placebo groups, respectively, had improved based  on assessments of global photographs. All efficacy endpoints were  numerically superior for the 1 mg dose over the 0.2 mg dose at 48 weeks.  Finasteride treatment was generally well tolerated. Finasteride 1  mg\day slows hair loss and improves hair growth in Japanese men with  male pattern hair loss.
非那雄胺是一种第二型 5α-还原酶的抑制剂，抑制睾固酮转化为二氢睾固酮DHT，DHT也就是造成典型男性掉发的关键所在  。本研究的目的是为了确定非那雄胺的最加剂量，并评估以非那雄胺治疗的日本雄性秃男性的疗效与安全性。在这个双盲随机研究中，  总共414个日本雄性秃男性参与研究，服用非那雄胺1毫克的有139位，服用非那雄胺0.2毫克的有137位，服用安慰剂有38位，每天服用一次，为期  48周。 
疗 效评估采用整体摄影评估、病人自我评估、和计划研究者评估。 在第12周的时候，显示所有服用非那雄胺的受试者都有显著的改善效果（P <  0.05 vs 安慰剂） 。在第48周，  透过照片评估，显示服用1mg受试者中有58%有效；服用0.2mg受试者中有54%有效；服用安慰剂受试者中有6%有效。  但在效果的差异上，48周后数