性秃与摄护腺癌都是与DHT有所相关，那雄性秃掉发比较有可能，或比较不可能得到摄护腺癌？
一项有938个男性受试者的研究回答了这个问题，而结果可能会令人感到惊讶！这对雄性秃的男士来说，也能算是一个好消息了！
雄性秃男性不只要应付将来可能发生的掉发，也必须应付潜在的健康问题，因为有许多的研究发现掉发与心脏疾病间的关 联。但最近发表的一个研究中，比较了938位男性的掉发模式、开始秃发的年龄、和一些其它的变数来找出这其中的关联。他们不只发现秃头与心脏病无关，还发 现在较年轻的时候秃头比较不容易患有前列腺癌。请看以下的研究
对患有前列腺癌的高风险男性来说，雄性秃不是一个有效的指标
Eur J Cancer. 2010 Jun 17
Cremers RG, Aben KK, Vermeulen SH, den Heijer M, van Oort IM, Kiemeney LA.
Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre, The Netherlands.
背景：男性贺尔蒙在摄护腺癌(PC)与雄性秃(AA)的病原生理学中扮演一个主要的角色。两种表现型间的关联与患有PC的高风险男性有关。我们在一个病例对照实验中评估各个年纪的AA与PC间的关联。
方法：938个从人口为罹患摄护腺癌症族群里取得的病患做为病例组(实验组)。 控制组(n=2160)是从一般男性中的随机取样。所有的受试者都完成癌症风险因子的问卷调查，其中包括使用改编自Hamilton-Norwood 量表(雄性秃七个分期)中关于头发在不同年龄时的外观、种族与摄护腺癌的家族史的问题。使用多变项罗吉斯回归分析比值比(ORs)和95%信赖区间。
结果：早年时秃发显示与患摄护腺 癌较低风险有关(20岁时秃发：OR=0.86; 95% CI 0.69-1.07 与40岁时秃发 OR=0.81; 95% CI 0.70-0.96)。完成问卷时显示，有雄性秃与患有摄护腺癌无关(OR=1.10; 95% CI 0.89-1.34.)。单独就”前额秃”或”顶秃”来说，在任何年龄时秃发都与患有摄护腺癌无显著相关。40岁时同时有”前额秃”与”顶秃”与降低患有 摄护腺癌风险有关(OR=0.62; 95% CI 0.45-0.86)。雄性秃与侵入性摄护腺癌之间没有关联。
结论：我们并没有发现各个年龄时患有雄性秃与摄护腺癌间有一致性的正相关。令人惊讶地是，如果要说其中有什么关系的话，这个研究指出，较年轻的时候得到雄性秃与患有摄护腺癌是呈负相关。因此，雄性秃对于将来患有摄护腺癌的高风险男性来说并不是一项有效的指标。
Androgenic alopecia is not useful as an indicator of men at high risk of prostate cancer.
Eur J Cancer. 2010 Jun 17
Cremers RG, Aben KK, Vermeulen SH, den Heijer M, van Oort IM, Kiemeney LA.
Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre, The Netherlands.
BACKGROUND: Androgens are assumed to play a central role in the pathophysiology of both prostate cancer (PC) and androgenic alopecia (AA). A correlation between the two phenotypes may be relevant for identification of men at high risk of PC. We evaluated the association between AA at different ages and PC in a large case-control study.
METHODS: The case group comprised 938 PC patients recruited from a population-based cancer registry. The controls (n=2160) were a random sample of the male general population. All subjects completed a questionnaire on risk factors for cancer, including questions on hair pattern at different ages using an adapted version of the Hamilton-Norwood scale, race and family history of PC. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using multivariable logistic regression.
RESULTS: Baldness at early age appeared to be associated with a lower risk of PC (baldness at age 20: OR=0.86; 95% CI 0.69-1.07 and baldness at age 40: OR=0.81; 95% CI 0.70-0.96). Baldness at completion of the questionnaire was not associated with PC: OR=1.10; 95% CI 0.89-1.34. An isolated 'frontal baldness' or 'vertex baldness' pattern was not significantly associated with PC at any age. Presence of a combined 'frontal and vertex' baldness pattern at age 40 was associated with a decreased risk of PC (OR=0.62; 95% CI 0.45-0.86). There were no significant associations between AA and aggressive PC.
CONCLUSIONS: We did not find consistent positive associations between AA at different ages and PC. Surprisingly, if anything, baldness at early age is inversely related to PC in this study. Androgenic alopecia is not useful as an indicator of men at high risk of PC. Copyright c 2010 Elsevier Ltd. All rights reserved.
