有时会因为忙碌而忘记每天服用一次保康丝(柔沛)或是保列治(波斯卡)，
甚至于吃了之后还会得了失忆症，忘了自己到底今天吃了没？
试想，有没有可能保康丝(柔沛)可以方便到一个月只吃一次，药效就可以持续？
根据最近在中国长沙中南大学进行的一个研究显示，长效型的Finasteride 1mg 在未来是可能的达到的。
这
种长效型保康丝(柔沛)的的创意是希望藉由将成分包裹在药中，随着时间而逐渐发挥药效，就可以免除每天服用一次的不便。在这个研究
中，Finasteride被包裹在propylene carbonate maleate
（PPCM）的胶囊中，实验结果显示，药效会在5～6周的时间逐渐释放。虽然这只是初步的实验，但因为已有其他长效型药物的成功案例，所以长效型的
Finasteride，在未来还是可以预期的喔！
不过我在想，这长效型保康丝(柔沛)虽然方便，但一颗要多少钱？
如果吃一星期就有副作用产生，该怎么办？ 留给科学家去伤脑筋吧！
资料出处：
Preparation of novel polymeric microspheres for controlled release of finasteride.Int J Pharm. 2007 May 13. Peng D, Huang K, Liu Y, Liu S.
College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China.
The utility of the novel polycarbonate, poly(propylene carbonate maleate) (PPCM) to encapsulate and control the release of finasteride, via microspheres, was investigated. The PPCM microspheres loaded with finasteride were elaborated by a simple oil-in-water (O/W) emulsion-solvent evaporation method. Various manufacturing parameters, including the concentration of polymer in dichloromethane (DCM) and the polymer:finasteride ratios were altered to optimize process variables during the microspheres production. The effects of these changes on the characteristics of the microspheres were examined. The structure and morphology were characterized by wide-angle X-ray diffraction (WXRD) and scanning electron microscopy (SEM). The results showed that the mean diameter of microspheres was approximately 2mum, and had both smooth and spherical surfaces. Greater encapsulation efficiency was obtained by increasing the ratios of polymer:finasteride and the concentration of PPCM in DCM. In vitro drug release of these microcapsules was performed in a pH 7.4 phosphate-buffered solution. The release profiles of finasteride from PPCM microcapsules were found to be biphasic with a burst release followed by a gradual release phase. A prolonged in vitro drug release profile was observed. After an initial burst, a continuous drug release was observed for up to 5-6 weeks.
